Cancer of the colon is the second most common cause of cancer deaths in the USA and there are few preventive strategies available to help fight this scourge. Some reports suggest that a diet high in animal fats and proteins increases the risk for colorectal cancer; but recent evidence has refuted that theory. Other studies have shown that bioactive compounds found in plant foods such as spices may help to counter this disease. Licorice is the latest spice to be studied in this context.